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Data sets collection RNA sequencing data and clinical annotations for ccRCC were obtained from The Cancer Genome Atlas (TCGA) via Synapse ( Additional microarray datasetsGSE12606, GSE31232, GSE36895, GSE73731 and GSE22541were downloaded from the GEO database ( Cell culture, transfection, and plasmids Human renal cancer cell lines 769-P (CLS Cat# 300106/p490_769-P, RRID: CVCL_1050), 786-O (RRID: CVCL_1051), and 293T (DSMZ Cat# ACC-305, RRID: CVCL_0045) were obtained from ATCC

Overweight and obesity are terms used to describe the excessive build-up of adiposity brought on by abnormalities in energy intake and expenditure 13

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Decreased tissue perfusion may lead to gradual infarction of organ tissues, such as the brain, liver, spleen, kidney, skeletal muscle, and so forth, with consequent release of intracellular enzymes

In vivo, LA can be reduced to dihydro LA (DH-LA) by dihydrolipoamide dehydrogenase [28]

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